Explanimation
23-10-2018

#Explanimation

Learn how our XPure Systems reduce chromatography costs in downstream processing by using Simulated Moving Bed technology and turn your batch processes into continuous processes. Find out which system fits your needs in this explanimation!

XPURE-R
28-09-2018

#XPURE-R

Resin is an integral part of any chromatographic process and often a big cost factor. Over time, the resin will deteriorate until it reaches the point where it needs to be replaced in order to maintain an economically viable process. As resin can be costly, you don’t want to replace it too early but predicting exactly when you should this can prove to be difficult when you're developing new processes. When the resin gets exposed to new combinations of products and chemicals, its lifetime may vary and you might need to replace it after 250 production cycles. Or maybe after 500? Or can the resin still deliver after 2000 cycles?

Without experimental data to back up the resin costs, it's quite difficult to write a robust business case for chromatography; the XPure-R is our answer to this challenge. The system enables you to age up to 10ml resin under your process conditions in a fully automated and time-efficient manner and can be tested in both fixed and expanded bed (EBA) mode.

XPure-R allows you to focus on your other research and will age your resin because it was designed to operate without attendance. All you need to do is prepare the XPure-R by supplying all the required process liquids, programming the recipe, and press run. 

It is also possible to outsource your resin aging studies to XPure, saving you even more time.

Examples:

The cycle time for an investigated process was reduced from 1 hour and 33 minutes to 7,5 minutes;  a 92% reduction.

For a resin aging experiment of 1000 cycles, the XPure-R reduced the experimental time from 64 days to only slightly over 5 days.

DOWNLOAD BROCHURE

XPure-E
07-03-2018

#XPure-E

PURIFICATION OF PROTEINS USING XPURE-E

(E.g. proteins from plant extract)


Expanded bed adsorption systems (EBA):

EBA chromatography effectively addresses the critical challenges of packed bed chromatography. It reduces e.g. clarification operations prior to the columns resulting in lower costs and improved yield. Minimal back pressure enables to achieve optimal scale of operation and productivity. The XPure-E system has been designed and built to perform EBA chromatography operation in a smooth and controlled fashion enabling:

  • Process development with enhanced scalability and operability
  • Handling viscous and turbid feed streams which are difficult to process through membranes or packed beds
  • Removal of clarifications steps prior to adsorption
  • 5-15 % increase in product yield
  • 2-4 x increase in productivity
  • 10-20 % reduction in waste
  • In-situ product removal and cell recycling (fermentation based streams)

DOWNLOAD BROCHURE

XPure General info
31-08-2017

#XPure General info

The static SMB system XPure-S that represents the by XPure patented valve system with a zero dead leg concept.
The carrousel SMB system XPure-C featuring a turn table that carries the sorption containers going through the distinct process steps of a typical IXchromatography cycle.

XPure offers SMB technology for product recovery and purification, comprising of

  • Feasibility studies
  • Developed simulation modelling software
  • Full-scale design
  • Start-up, validation, maintenance and (process) service

and

  • Is not related to any manufacturer of resins
  • Applies originally manufactured components or and fabricates that are consistent with clients material standards
  • Optional elements
  • vessels and liquid distributors
  • (inter)connecting piping and auxiliary equipment

Download brochure

XPure-C
31-08-2017

#XPure-C

LAB SYSTEM FOR SEPARATION, PURIFICATION, AND RECOVERY

  • It is the preferred technology to perform a continuous separation, purification and recovery with any feed solution
  • It is a reliable continuous system due to the use of high-quality components and materials
  • Bench-scale carrousel system with a powerful tool to evaluate design parameters and perform process simulation

DOWNLOAD BROCHURE

XPure-S
31-08-2017

#XPure-S

SYSTEM FOR SEPARATION, PURIFICATION, AND RECOVERY

The XPure-S SMB system offers a system for ion exchange processes with virtually unlimited scalability. The columns are not mounted on a carrousel and the valve manifolds can be designed to allow very large hydraulic throughputs. This makes the system suitable for any scale of operation.

In addition to this, the modular design of the fluid distribution system allows extension in a later stage without significant extra investments, by connecting additional valve manifolds and extra columns (and resin volume). This allows a stage-wise capacity extension of the plant without having to build an entirely new system.

DOWNLOAD BROCHURE