
Efficient Capture and Recovery from Complex Streams
XPure-S simulated moving bed (SMB) system is the preferred technology to perform a continuous separation, purification, and recovery with a feed solution. It is built with an emphasis on scalability and operational flexibility that enables its application in solving a broad range of separation challenges, from small pilot to industrial scale. The columns are connected to valve manifolds which are designed to allow very large hydraulic throughputs, making the system suitable for any scale of operation.
In addition, the modular design of the fluid distribution system allows extension at a later stage without significant extra investment by connecting additional valve manifolds and extra columns (and resin volume). This allows a stage-wise capacity extension of the plant without having to build an entirely new system.
- System design enabling SMB chromatography or multiple batch runs
- Easy to scale and operate
- Robust mechanicals that can even process unclarified fermentation broth
- High degree of flexibility for both equipment and automation design
- Relatively small footprint
Composition and Specifications of the XPure-S SMB Chromatography System
- Valve blocks dedicated to every single column, integrated to one valve block
- Multiple pumps
- Monitor and control system closing and opening valves based on time or sensors
- Tubing between pumps, valve block, and columns
- Minimum of 4 static columns, with maximum to 16 static columns configuration

SMB addition
The XPure-SE system offers expanded bed control for each individual column.
- One pump every column
- One Level Transmitter every column
- One in-line strainer (resin trap) at every column outlet
- Level control for all expanded bed zones, integrated in process control system
XPure-S & XPure-SE Technical Facts
Improve purity and yield of target molecules to ensure high-quality ingredients for product manufacturers
See HowThe XPure Advantage

Easy to Use
XPure hardware and software are designed for easy operation and the flexibility to implement a wide range of process control strategies

Scalable to Your Needs
Simple and modular multi-column hardware is designed to scale from lab or pilot to industrial scale

Service Excellence
Our team of experts is dedicated to providing cost effective purification process solutions tailored to your specific needs